Pyrroloquinoline quinone (PQQ) is a novel compound that has garnered attention for its potential health benefits, particularly in the realm of cellular energy production and oxidative stress mitigation. With the global emergence of COVID-19, a disease triggered by the SARS-CoV-2 virus, researchers and health professionals have been exploring various avenues to bolster immune function and enhance recovery in infected individuals. This article delves into the potential influence of PQQ in the context of COVID-19.